ORGN 632 |
| Azide based reagents are used extensively in photoaffinity labeling and cross-linking studies to discover points of contact between macromolecules and to map out binding domains. Historically, commercially available azide reagents have been used in these studies despite the fact that model studies in organic media indicate that they do not undergo the desired photochemical pathways. For this reason new azide reagents with favorable properties need to be synthesized and their photochemistry in water medium needs to be evaluated. We are involved in designing and synthesizing new azide analogs of nucleosides. The photochemistry of these new modified nucleosides will be studied in aqueous medium to gain knowledge about the lifetime of light generated reactive intermediates using time resolved (fs-ms) spectroscopic techniques. The details of their synthesis and photochemistry will be discussed. |
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |