Nature-inspired peptidomimicry: Growth of β-peptides on glass surfaces

ORGN 642

Abbas G. Shilabin1, Scott McN. Sieburth, scott.sieburth@temple.edu1, George Baran, grbaran@temple.edu2, and Quan Wan, qwan@temple.edu2. (1) Department of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA 19122, (2) Center for Bioengineering and Biomaterials, College of Engineering, Temple University, 1947 N. 12th Street, Philadelphia, PA 19122
Mother of pearl (nacre) is a composite that is 95% inorganic solid held together with a flexible protein mortar. The composite is orders of magnitude stronger than the inorganic component alone. As part of a program to engineer stronger composite materials, we have investigated the growth of β-peptides on glass surfaces. β-Amino acids have more substitution options than the standard α-amino acids and their β-peptides can mimic all of the natural protein secondary structures. We will present our studies of β-peptide polymers covalently grown from glass surfaces.