ORGN 692 |
| (2S)-1-{(R)-[1-(cyclopropylsulfonyl)piperidin-4-yl](3-fluoro-phenyl)methyl}-2-methylpiperazinedium hydrobromide (1) is an intermediate in the synthesis of a drug substance in development. An improved synthesis was developed. A key feature of the process is the trapping of a low-melting, difficult to handle aldehyde as a benzotriazole adduct that has improved physical properties. |
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |