FePt magnetic nanoparticles syntheses, cell toxicity studies and as MRI contrast agent

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Shu Chen1, Lijun Wang2, Stuart Brown2, David Cole-Hamilton3, Stephen Lee1, Andreas Melzer2, Sir Alfred Cuschieri2, and Pascal André, Pascal.Andre@st-andrews.ac.uk1. (1) School of Physics & Astronomy (SUPA), University of St Andrews, St Andrews, NA, United Kingdom, (2) Institute for Medical Science and Technology (IMSaT), University of Dundee, Dundee, United Kingdom, (3) School of Chemistry (EaStChem), University of St Andrews, St Andrews, United Kingdom

FePt magnetic nanoparticles offer great interests for biomedical applications such as magnetic separation, drug delivery, hyperthermia and MRI, because its high magnetic anisotropy is one of the highest of any known material.[1] A natural question arises regarding the potential toxicity and biomedical applications of fcc-FePt.

In this context, we describe recent promising progresses in the syntheses of low polydispersity 1:1 ratio FePt NPs and their use as negative MRI contrast agents. ~ 5 nm fcc FePt NPs were synthesized by a modified thermal decomposition method & made to be water soluble by coating with NPs surface with cysteamine. Cytotoxicity studies of FePt NPs were carried out on A375M cell, while cell uptake of NPs through endocytosis was confirmed by TEM study. Longitudinal and transverse relaxations of cysteamine coated FePts was measured, with results suggest that fcc-FePt NPs already display superior properties when compared to commercial existing negative contrast agents. ADDIN EN.CITE Chen222452224517Chen, S. Wang, L. Brown, S. Cole-Hamilton, D.J. Lee, S. Melzer, A. Cuschieri, A. André, PAscalIron-Platinum Nanoparticles for Bio-Medical ApplicationsIn preparationIn preparation

in preparationin preparation[2]

10 nm

250 nm

(1) Sun, S. H.. Advanced Materials 2006, 18, (4), 393-403.

(2) Chen, S.; Wang, L.; Brown, S.; Cole-Hamilton, D. J.; Lee, S.; Melzer, A.; Cuschieri, A.; André, P. In preparation.