Creating data resources for biology: Lessons from the PDB and the PSI SGKB


Helen M. Berman, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854
Many issues need to be considered when building resources that enable a variety of scientific communities. One is the necessity of a scalable infrastructure that can handle vast amounts and different types of data. This infrastructure must also be extensible to handle new and evolving technologies. Another concern is how to solicit and incorporate the needs and wants of a variety of user communities. Two global resources for science the Protein Data Bank (PDB) and the Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB) will be presented. The PDB has been the archive for the three-dimensional coordinates for experimentally-determined biological structures for the last 30 years. The PSI SGKB, launched in 2007, expands upon this information by integrating available structural, experimental, biological, and modeling data for all protein sequences. Today, both resources are used by researchers and students in a variety of disciplines who are studying these biological macromolecules and their relationships to sequence, function, and disease.

Herman Skolnik Award Symposium
8:30 AM-11:45 AM, Tuesday, August 18, 2009 Walter E. Washington Convention Center -- 204C, Oral

Division of Chemical Information

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009