Metal-linked oligopeptide duplexes: Self-complementary di- and tri-peptides

INOR 192

Matthew B. Coppock, mbw@chem.psu.edu, Hye Won Youm, Lauren A. Levine, mbw@chem.psu.edu, Carl P. Myers, mbw@chem.psu.edu, and Mary Elizabeth Williams, mbw@chem.psu.edu. Department of Chemistry, The Pennsylvania State University, 104 Chemistry Research Building, University Park, PA 16802
We present the synthesis and characterization of three self-complementary oligopeptides that use Cu+2 complexation to form duplex structures. An aminoethylglycine (aeg) backbone is functionalized with a specific ordering of pyridine (py), methyl bipyridine (bpy), terpyridine (tpy) or phenyl terpyridine (ph-tpy) ligands. We report the solution phase synthesis of two dipeptides, Fmoc-aeg(py)-aeg(tpy)-OtBu and Fmoc-aeg(py)-aeg(ph-tpy)-OtBu, and the tripeptide Fmoc-aeg(py)-aeg(bpy)-aeg(tpy)-OtBu. These react with Cu+2 to form the metalated duplexes with two and three metals, respectively. Because of the relative denticity of the ligands, the two oligopeptide chains have an antiparallel alignment in the duplexes. The peptides and Cu-linked complexes are fully characterized using NMR, mass spectrometry, elemental analysis and absorbance spectroscopy. Because the metal-metal distances and number of metals change for the three duplexes, we use EPR spectroscopy to examine and compare their spin coupling.
 

General Inorganic Chemistry
7:00 PM-9:00 PM, Sunday, August 16, 2009 Walter E. Washington Convention Center -- Hall D, Poster

Division of Inorganic Chemistry

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009