Inhibitory effects of Michelia alba on matrix metalloproteinases expression: Application in preventing photoaging

AGFD 150

Kuo-Ching Wen, kcwen0520@mail.cmu.edu.tw1, Tsen-Jung Lin, cathyletter@hotmail.com2, Yin-Chih Chien, stacy592@yahoo.com.tw2, I-Chen Shih, pin815@yahoo.com.tw2, and Hsiu-Mei Chiang, hmchiang@mail.cmu.edu.tw1. (1) School of Cosmeceutics, China Medical University, 91, Hsueh-Shih Road, Taichung, Taiwan, (2) Institute of Pharmacy, China Medical University, 91, Hsueh-Shih Road, Taichung, Taiwan
UV radiation from the sun an cause skin photoaging by inducing matrix metalloproteinases (MMPs). It had been reported that, MMP-1 -3, and -9 in particular can degrade collagen and reduce skin elasticity. Polyphenols are a group of compounds that possess a variety of biological activities which include inhibition of MMPs and elastase. In this study, Michelia alba (MA) which possess polyphenols was investigated for protective activity. MA methanolic extract was subject to MMPs activity and expression inhibition tests in UVB-induced human skin fibroblasts. The results showed that MA inhibited collagenase activity and UVB-induced MMPs. MA inhibited UVB-induced ERK and JNK kinase but not p38 kinase. MA may regulate the expression of MMP-1 and MMP-3 by UVB irradiation via the ERK and JNK kinase pathway. MA treatment may prevent UVB-induced extracellular matrix damage by inhibiting the expression of MMP-1 and MMP-3.
 

General Posters
2:00 PM-4:00 PM, Tuesday, August 18, 2009 Renaissance Washington -- Renaissance East, Poster

Division of Agricultural & Food Chemistry

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009