Web services to promote GPCRs peptide mimetics

COMP 275

Wataru Nemoto, w.nemoto@aist.go.jp1, Kazuhiko Fukui, k-fukui@aist.go.jp1, and Hiroyuki Toh, toh@bioreg.kyushu-u.ac.jp2. (1) Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo, 135-0064, Japan, (2) Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan
G-Protein Coupled Receptors (GPCRs) are one of the most important targets for pharmaceutical medicines. Recent study revealed that many GPCRs are able to form homo- and/or hetero-oligomers, and the functional importance of the oligomerization has been extensively investigated. These studies revealed the combinations of subtypes required for complex formation and the wide variety of functions of the oligomers. In contrast to this situation, the molecular mechanisms of oligomerization are not fully understood yet. Under such restrictions, accurate predictions of the interfaces will accelerate investigations of the molecular mechanisms of oligomerization and promote the drug discovery for GPCRs based on peptide mimetics approach. Therefore, we recently launched a web service to predict the interfaces for GPCR oligomerization, named G-protein coupled Receptors Interaction Partners (GRIP) (http://grip.cbrc.jp/GRIP/index.html). In addition, we are developing a database for providing information about GPCR oligomerization.

Poster Session
6:00 PM-8:00 PM, Tuesday, August 18, 2009 Walter E. Washington Convention Center -- Ballroom A, Poster

Division of Computers in Chemistry

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009