ORGN 790 |
A unified approach to the ‘miscellaneous' subset of Lycopodium alkaloids has been developed. A key element is the elaboration of tricyclic cycloheptadiene 3 to form the common tetracyclic intermediate 2. Our strategy has been employed to achieve the enantioselective synthesis of the pentacyclic alkaloid (+)-lyconadin A (1). The key reaction involves an oxidative cyclization to form the crucial C-N bond to complete the pentacyclic core of the lyconadins. Studies on this novel transformation have been conducted to understand the mechanism of this process. |
Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |