ORGN 663 |
| In a recent report, Nielsen and Skrydstrup (J. Amer. Chem. Soc. 2008, 130, 13145.) demonstrated that addition of a silyllithium reagent to the Ellman sulfinimine (1, R = t-Bu) yields the α-amino silane 3 with excellent diastereoselectivity. This efficient approach to these structures has been studied with both Ellman and Davis (R = p-MePh) sulfinimines in the context of silanediol protease inhibitor synthesis.
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Sci-Mix
Division of Organic Chemistry |
