Stereoslective synthesis of multifunctionalized dihydrofuran through condensation of nitroalkene, aldehyde, and 1,3-diiketone

ORGN 755

Cheng Zhong,, Lekh Nath Sharma Gautam,, and Xiaodong Shi. C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Prospect Street, Morgantown, WV 26506
Highly functionalized dihydrofuran(DHF) was synthesized through an stereoselective three component condensation. High yield and single diastereomer was obtained in all cases. Different catalyst systems had been evaluated for this transformation. With the different functional groups on the DHF substrates, further transformation led to complex natural product backbone synthesis in an efficient way.