ORGN 741 |
| Quinoxalinone and its tricyclic analogues are interesting previleged scaffolds in drug discovery process. They can be found as core structures in many pharmaceutically important compounds. In this poster, a practical method to the synthesis of a series of pharmaceutically interesting quinoxalinone scaffolds (21 examples)will be disclosed. The key step involves intramolecular palladium-catalyzed N-arylation through the use of microwave irradiation. The reaction tolerates many substituted bromo anilides to ensure quick delivery of diversified small molecules in parallel. Conventional heating can also be applied to synthesizethe scaffolds in gram scale. The limitation and scope of this methodology will also be discussed.
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |
