Direct patterning of a cyclotriveratrylene (CTV) derivative on a gold surface for host-guest applications

ORGN 695

Zachary Osner, zosner@luc.edu1, Richard C. Holz, rholz1@luc.edu2, Daniel Becker, dbecke3@luc.edu1, and Dorjderem Nyamjav, dnyamjn@luc.edu2. (1) Department of Chemistry, Loyola University Chicago, 1068 West Sheridan Road, Flanner Hall, Chicago, IL 60626, (2) Department of Chemistry, Loyola University-Chicago, 1068 West Sheridan Road, Chicago, IL 60626
Host-guest chemistry involves the complimentary binding between two molecules and can serve as the basis for analytical detection and signaling, as well as a model for receptor-ligand binding in biological systems. Host molecules have been synthesized to selectively bind proteins and enzymes, and have been used as optical sensors, electrochemical sensors, and supramolecular catalysts. Cyclotriveratrylene (CTV), a common supramolecular scaffold, has been extensively employed in guest-host chemistry. CTV-oxime derivatives in crown and saddle conformations with a thiotic acid sulfur linkage have been synthesized for direct patterning on a gold surface via Dip-Pen Nanolithography (DPN). Tapping mode atomic force microscopy (TMAFM) data provided evidence for the ability to directly write supramolecular SAMs on a surface with evidence obtained for binding of guests at the surface.