Highly-functionalized piperidine synthesis through a condensation of primary amine, nitro alkene, and enone

ORGN 716

Cheng Zhong, czhong@mix.wvu.edu, Xiaodong Shi, and Yunfeng Chen, yfchen@gmail.com. C. Eugene Bennett Department of Chemistry, West Virginia University, 217 Clark Hall, Prospect Street, Morgantown, WV 26506
An convenient method for synthesis multi-functionalized pepiridine was developed through the condensation of primary amine, beta-nitro styrene and enone. Not only high yield and mild conditions for the reaction, high to excellent diastereoselectivity was obtained.