ORGN 702 |
| The synthesis of the biologically active polypropionate macrolide apoptolidin C is currently under investigation. This synthesis highlights a catalytic asymmetric approach to structurally complex polypropionate arrays based on our acyl halide-aldehyde cyclocondensation (AAC) reaction. Employing the AAC technology using cinchona alkaloid derived catalysts, we have successfully demonstrated a catalytic and asymmetric synthesis of the aglycone core of apoptolidin C. This presentation describes the synthesis of the C12-C28 synthon, starting from the readily available methoxy acetaldehyde and completion of the aglycone core.
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |
