A family of tunable hybrid phosphorus ligands for highly enantioselective asymmetric hydroformylation

ORGN 653

Xiaowei Zhang, zhangxw@rutgers.edu, Bonan Cao, bonan@eden.rutgers.edu, and Xumu Zhang, xumu@rci.rutgers.edu. Department of Chemistry and Chemical Biology & Pharmaceutical Chemistry, Rutgers, The State UniVersity of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854
By introducing different groups onto 3, 3'-position of binaphthyl fragments and changing the N-substituents, a series of phosphine-phosphoramidite ligands were designed and synthesized. To understand the relationship between the substituents and the ligand performance, those ligands were applied in enantioselective asymmetric hydroformylations of styrene, vinyl acetate and allyl cyanide. Excellent enatioselectivityies (up to 98% ee) had been achieved.