Bismuth salts-catalyzed easy and highly efficient route to the synthesis of versatile α-amino phosphonates

ORGN 645

Debasish Bandyopadhyay, bandyopad@utpa.edu1, Antara Banik, banik@utpa.edu2, Sahil Bhatta2, and Bimal K. Banik, banik@panam.edu3. (1) Department of Chemistry, University of Texas-Pan American, 1201 W. University Drive, Edinburg, TX 78539, (2) Department of Chemistry, Department of Chemistry, University of Texas-Pan American, 1201 W. University Drive, Edinburg, 78539, (3) Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78541
-Amino phosphonates, due to their structural analogy to -amino acids, have been the subject of considerable current interest. A number of synthetic methods have been reported for the synthesis of -amino phosphonates during past few decades. Of these methods, the nucleophilic addition of phosphites to imines, catalyzed by a base or an acid, is the most convenient. The catalytic activity of a series of bismuth salts has been studied. Our bismuth salts-induced procedure has notable advantages that include simple operation, environment friendly conditions, faster reactions and high yields of products.