Bismuth salts-catalyzed easy and highly efficient route to the synthesis of versatile α-amino phosphonates

ORGN 645

Debasish Bandyopadhyay, bandyopad@utpa.edu1, Antara Banik, banik@utpa.edu2, Sahil Bhatta2, and Bimal K. Banik, banik@panam.edu3. (1) Department of Chemistry, University of Texas-Pan American, 1201 W. University Drive, Edinburg, TX 78539, (2) Department of Chemistry, Department of Chemistry, University of Texas-Pan American, 1201 W. University Drive, Edinburg, 78539, (3) Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78541
á-Amino phosphonates, due to their structural analogy to á-amino acids, have been the subject of considerable current interest. A number of synthetic methods have been reported for the synthesis of á-amino phosphonates during past few decades. Of these methods, the nucleophilic addition of phosphites to imines, catalyzed by a base or an acid, is the most convenient. The catalytic activity of a series of bismuth salts has been studied. Our bismuth salts-induced procedure has notable advantages that include simple operation, environment friendly conditions, faster reactions and high yields of products.

 

Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster

Division of Organic Chemistry

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009