De novo synthesis of the trisaccharide subunit of landomycin A and E

ORGN 680

Ehesan U Sharif, esharif@mix.wvu.edu, Department of Chemistry, West Virginia University, 217 Clark Hall, Prospect St., Morgantown, WV 26505 and George A. O'Doherty, george.odoherty@mail.wvu.edu, C. Eugene Bennett Department of Chemistry, West Virgnia University, 284 Prospect Street, 217 Clark Hall, Morgantown, WV 26506.
The anticancer natural product Landomycin A has been of interest to the synthetic and biology community due to its potent anti tumor activity. Using our recently developed de novo approach to oligosaccharides, we have been pursuing the synthesis of the hexasaccharide portion of Landomycin A. Our successful approach to the trisaccharide portion of Landomycin E will be presented as well as our effort toward the total synthesis of Landomycin A.
 

Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 17, 2009 Walter E. Washington Convention Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009