ORGN 756 |
| While we investigate chiral auxiliaries in 8π (8π, 6π) electrocyclization for preparing enantiomerically pure SNF analogues, we initially obtained two endo diastereomeric products with low diastereoselectivity. And, separation of diastereomeric products was challenging. Recently, we found a model system which can be easily separated on chromatography. In addition, new auxiliaries for this asymmetric 8π electrocyclization are under active investigation. This approach could allow to prepare enantiomerically pure natural products containing bicyclo[4.2.0]-2,4-octadiene core as well as SNF analogues.
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |
