Trifluoroacetic acid-mediated facile construction of 6-substituted phenanthridines

ORGN 789

So Won Youn, so_wony@hotmail.com, Joon Hyung Bihn, jessose@nate.com, Su Kyung Ock, entia09@nate.com, and Ja Ok Park, yo2565@naver.com. Department of Chemistry, Pukyong National University, Busan, 608-737, South Korea
Phenanthridines have attracted considerable attention in medicinal chemistry and in material science due to their biological activity and their presence in a variety of significant natural products and synthetic dye-stuffs. recently we have developed simple and convenient one-pot procedure, TFA-mediated reaction of 2-arylanilines with arylaldehydes to afford 6-substituted phenanthridines. The operational simplicity of this process and use of simple reactants without requirement of synthesis of complicated precursors, strictly anhydrous conditions, air-sensitive organometallic reagents, or expensive metal catalysts make it particularly attractive for library construction.