Trifluoroacetic acid-mediated facile construction of 6-substituted phenanthridines

ORGN 789

So Won Youn,, Joon Hyung Bihn,, Su Kyung Ock,, and Ja Ok Park, Department of Chemistry, Pukyong National University, Busan, 608-737, South Korea
Phenanthridines have attracted considerable attention in medicinal chemistry and in material science due to their biological activity and their presence in a variety of significant natural products and synthetic dye-stuffs. recently we have developed simple and convenient one-pot procedure, TFA-mediated reaction of 2-arylanilines with arylaldehydes to afford 6-substituted phenanthridines. The operational simplicity of this process and use of simple reactants without requirement of synthesis of complicated precursors, strictly anhydrous conditions, air-sensitive organometallic reagents, or expensive metal catalysts make it particularly attractive for library construction.