Catalytic asymmetric C-CN activation: Cyanoamidation of alkenes and the total synthesis of (-) horsfiline and (-) coerulescine

ORGN 669

Venkata Jaganmohan Reddy,, Department of chemistry/prof. Chris Douglas, University of MInnesota Twin Cities, 566 Kolthoff Hall, 225 Pleasant St SE, Minneapolis, MN 55455 and Christopher J. Douglas, Department of Chemistry, University of Minnesota, Smith and Kolthoff Halls, 207 Pleasant Street SE, Minneapolis, MN 55455-0431.
Development of C-C sigma bond activation has the potential to have an impact on natural product synthesis, much like recent work in C-H activation. One of the most important areas in this field is activation of organonitriles (C-CN bond activation), with different metals reacting in both a stoichometric and catalytic processes. We report a catalytic asymmetric C-CN bond activation and will showcase our findings in the context of total synthesis of (-) horsfilin and (-) coerulescine.