Highly enantio- and diastereoselective organocatalytic desymmetrization of prochiral cyclohexanones by simple direct aldol reaction catalyzed by proline

ORGN 683

Xavier Companyó, x.companyo@hotmail.com1, Guillem Valero1, Luis Crovetto, Luiscrovetto@ugr.es2, Albert Moyano, amoyano@ub.edu1, and Ramon Rios, riosramon@yahoo.com1. (1) Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès, 1-11, Barcelona, 08028, Spain, (2) Department of Physical Chemistry, University of Granada, Cartuja Campus, Granada 18071, Spain, 18071 Granada, Spain
The addition of hydrogen bond donors dramatically improves the catalytic efficiency of proline in desymmetrization reactions.