A new, practical, conformational reporter.

ORGN 655

Benjamin W. Gung, gungbw@muohio.edu and Bright Emenike, emenikbu@muohio.edu. Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056
Triptycene-derived compounds bearing trifluoromethyl groups at the ortho position of a benzoyl group has been prepared to serve as a conformational equilibrium reporter for directed measurements of arene-arene interactions. A series of such compounds bearing arenes with different substituents groups were synthesized. The ratio of syn and anti conformers were determined and compared to the ratio of syn and anti conformers with trifluoromethyl at the para position.