Synthesis and biological evaluation of novel compounds containing fused bicyclic systems, including indolizidine and quinolizidine

ORGN 760

Antonella Pepe, pepea@mail.nih.gov, Laboratory of Synthetic Chemistry, National Cancer Institute, SAIC-Frederick, 1050 Boyles Street, Frederick, MD 21702 and Sanjay V. Malhotra, malhotrasa@mail.nih.gov, Laboratory of Synthetic Chemistry, National Cancer Institute - Frederick, SAIC-Frederick, 1050 Boyles Street, Frederick, MD 21702.
Indolizidine and quinolizidine alkaloids are large families of natural products isolated from diverse sources including ants, frogs, fungi and plants. The interesting biological activity of these classes of compounds renders these fused bicyclic rings extremely valuable scaffolds for drug discovery. We have recently developed a novel synthesis for the effective preparation of these ring systems. Here we report the synthesis and the biological evaluation of a series of compounds containing different fused byciclic rings, including indolizidines and quinolizidines.