First organocatalytic kinetic resolution of compounds with planar quirality

ORGN 685

Andrea-Nekane Alba, n3k4n3@yahoo.es, Albert Moyano, amoyano@ub.edu, and Ramon Rios, riosramon@yahoo.com. Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès, 1-11, Barcelona, 08028, Spain
The first organocatalytic kinetic resolution of 2-substituted ferrocenecarbaldehyde is reported. The use of aldol or Mannich reaction gives access to both enantiomers of starting material by using the same catalyst (L-proline). We have obtained selectivity factors up to 9,2.