Fragmentation of 3,4-dihydropapaveraldinium salt

WCC 13

Nicole M. Kennedy, Chemical Development, Roche Carolina Inc, 1201 Gregg Avenue, Florence, SC 29501
It has been known for some time that the cleavage of a carbon-carbon bond results in a stabilized carbanion. Recently, the mechanism has been elucidated and the cleavage of the carbon-carbon bond has resulted in fragmented compounds consisting of benzylisoquinolines. Current work focuses on (1) exploiting the concise synthetic sequence for fragmentation and (2) expanding the methodology for the preparation of other benzylisoquinoline analogues. Some of the target molecules may exhibit pharmacology acitivty in the treatment of Alzheimer's disease.
 

The Merck Index Women in Chemistry
2:30 PM-4:30 PM, Monday, August 17, 2009 Walter E. Washington Convention Center -- Hall D, Poster

Women Chemists Committee

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009