ORGN 757 |
In recent years, oxazolidinone compounds have been discovered as a new antibiotic agent for the effective therapy to antibiotic-resistant species. In this work, we have studied the intramolecular cyclization of N-BOC-protected epoxy amine intermediate(1) under the acidic condition to afford oxazolidinone intermediate(2) and also tested the resolution of the amine intermediate(3) with several chiral acids to give a chiral oxazolidinone intermediate(4) for linezolid. |
Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |