Synthetic studies of pharmaceutically important N-alkylated-4-alkoxypiperidine intermediates for the antihistamine drug

ORGN 779

Soo Jeong Kim, dororol@naver.com1, HoonGyu Park1, Hakwon Kim, hwkim@khu.ac.kr2, and Sea Han Oh3. (1) Department of Chemistry, KyungHee University, Seocheon-dong, Giheung-gu, Gyeonggi-do, Yongin-si, 446-701, South Korea, (2) Department of Chemistry and The Institute of Natural Science, Kyung Hee University, Seocheon-dong, Giheung-gu, Yongin-si, Gyeonggi-do, 446-701, South Korea, (3) PharmswellBio Co., Ltd
Many compounds including piperidine structures are widely used as a medicine such as Bepotastine, antihistamine drug and Tirofiban, antiplatelet drug. Therefore, the efficient synthetic methods of N-alkylated-4-alkoypiperidines must be developed. In this work, several routes for a piperidine ring formation have been studied and further elaboration of piperidine intermediates has been done for the preparation of antihistamine drug, bepotastine.

 

Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster

Division of Organic Chemistry

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009