Highly enantioselective organocatalytic synthesis of piperidines.

ORGN 686

Ramon Rios, riosramon@yahoo.com1, Guillem Valero1, Jiri Schimer2, Jan Vesely, jxvesely@post.cz2, and Albert Moyano, amoyano@ub.edu1. (1) Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès, 1-11, Barcelona, 08028, Spain, (2) Department of Organic Chemistry, Charles University, Hlavova 2030, 128 00 Prague, Prague, NA, Czech Republic
A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines yielding the corresponding adducts with high yields and enantioselectivities. Moreover this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only 3 steps