In(III)-PyBox complex catalyzed highly enantioselective carbonyl-ene reactions

ORGN 793

Jun-Feng Zhao Sr., zhao0065@ntu.edu.sg, Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Nanyang Technological University, SPMS-04-01, 21 Nanyang Link, Singapore, 637371, Singapore and Teck Peng Loh, teckpeng@ntu.edu.sg, Divison of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 1 Nanyang Walk, Singapore, 639798, Singapore.
Carbonyl-ene reactions have gained tremendous attention because it allows the atom-economic construction of homoallylic alcohols, which are important building blocks for the synthesis of many natural products and pharmaceutical compounds. Metal complex derived from Al, Ti, Cu, Sc, Co, Pd, Pt, Cr, as well as organocatalyst had been used to mediate the asymmetric carbonyl-ene reaction. While extraordinary advances have been achieved, most of them still have limitations such as high catalyst loading, harsh reaction conditions, limited substrate scope or difficult preparation of catalyst. Therefore, the asymmetric carbonyl-ene reaction remains a challenging topic. Herein, we reported the chiral In(III)-Pybox complex catalyzed highly enantioselective carbonyl-ene reaction and the significant counterion effect in this system.