ORGN 793 |
| Carbonyl-ene reactions have gained tremendous attention because it allows the atom-economic construction of homoallylic alcohols, which are important building blocks for the synthesis of many natural products and pharmaceutical compounds. Metal complex derived from Al, Ti, Cu, Sc, Co, Pd, Pt, Cr, as well as organocatalyst had been used to mediate the asymmetric carbonyl-ene reaction. While extraordinary advances have been achieved, most of them still have limitations such as high catalyst loading, harsh reaction conditions, limited substrate scope or difficult preparation of catalyst. Therefore, the asymmetric carbonyl-ene reaction remains a challenging topic. Herein, we reported the chiral In(III)-Pybox complex catalyzed highly enantioselective carbonyl-ene reaction and the significant counterion effect in this system.
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |
