Novel and efficient synthesis of 4-sulfonyl-2-pyridones

ORGN 733

Martha L. Minich, martha.l.minich@pfizer.com1, Isa D Watson2, Kevin Filipski1, and Jeffrey A. Pfefferkorn, jeffrey.a.pfefferkorn@pfizer.com1. (1) Pfizer Global Research and Development, Pfizer Inc, Eastern Point Road, Groton, CT 06340, (2) Department of Chemistry, Hampton University, Hampton, VA 23668
Heterocyclic 4-sulfonyl-2-pyridinones represent useful scaffolds for drug discovery and are also versatile synthetic building blocks. Herein we describe a novel and efficient synthesis of this heterocyclic ring system utilizing an acid mediated cyclo-condensation reaction. This synthetic method affords convenient access to structurally diverse N-substituted 4-sulfonyl-2-pyridinones in moderate to good yields.


Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster

8:00 PM-10:00 PM, Monday, August 17, 2009 Walter E. Washington Convention Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 238th ACS National Meeting, Washington, DC, August 16-20, 2009