ORGN 758 |
| Peduncularine is an alkaloid first isolated in 1971 and is known to have some cytotoxic activity against human breast cancer cells. It contains an unusual 6-azabicyclo[3.2.1]oct-3-ene core which, as we envisaged, can be assembled from known epoxytropinone (1) (2 steps from N-alkoxycarbonyl pyrrole) using a novel cascade process to generate racemic ketone (2).
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Heterocycles and Aromatics, Asymmetric Reactions and Syntheses and Total Synthesis of Complex Molecules
7:00 PM-9:00 PM, Wednesday, August 19, 2009 Walter E. Washington Convention Center -- Ballroom C, Poster
Division of Organic Chemistry |
