Synthesis of deuterium-labeled camptothecin and derivatives

ORGN 772

Heiko Junga, heiko.junga@covance.com, Christopher James Randlett, and Xiangyu Jiang. Bioanalytical Chemistry, Covance Laboratories Inc, 3301 Kinsman Blvd., Madison, WI 53704
Camptothecin-d5, 10-hydroxy-Camptothecin-d5 and Irinotecan SN-38-d5 metabolite were synthesized as racemates via multiple steps. These deuterated internal standards allowed the development of simple and rugged LC-MS/MS methods.