Aqueous fluorometric and colorimetric sensing of phosphate ions by a fluorescent dinuclear zinc complex of a lysine-based ligand

INOR 449

Snehadrinarayan Khatua, s.khatua@kaist.ac.kr1, Shin Hei Choi, shchoi@kaist.ac.kr1, Junseong Lee2, and David G. Churchill, dchurchill@kaist.ac.kr1. (1) Department of Chemistry and School of Molecular Science (BK 21), Molecular Logic Gate Laboratory, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon, 305-701, South Korea, (2) Department of Chemistry and School of Molecular Science (BK 21), Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon, 305-701, South Korea
Anions play a vital role in chemistry and biology, and the design and synthesis of anion- selective receptors or sensor has received considerable attention. [1] The development of selective receptors for phosphate derivatives, such as adenosine triphosphate (ATP), ADP, inorganic pyrophosphate (PPi), and phosphoproteins is of particular interest because they play vital roles in a wide range of life processes, such as energy storage, signal transduction and gene construction. [2] The pyrophosphate ion is especially a biologically important target because it is the product of ATP hydrolysis under cellular conditions. While a variety of fluorescent chemosensors that can selectively recognize PPi have been reported, only a few can function for PPi in a pure aqueous solution, both by fluorometric and colorimetric methods. [3] Herein, we report the synthesis and structure of a dimeric zinc complex, [Zn2(slys)2Cl2](CH3OH)2(H2O)3 (Figure) [H2slys = 6-amino-2-{(2-hydroxybenzylidene) amino}hexanoic acid] from an in situ formed lysine-based ligand. The sensing of phosphate ions (PPi, ATP and ADP) was possible both by fluorometric and colourimetric methods in water. [1] P. D. Beer, P. A. Gale, Angew. Chem., Int. Ed., 2001, 40, 486.[2] D. H. Lee, S. Y. Kim, J.-I. Hong, Angew. Chem. Int. Ed. 2004, 43, 4777.[3] D.H.Lee, J. H. Im, S. U. Son, Y. K. Chung, J.-I. Hong J. Am. Chem. Soc. 2003, 125, 7752

 

Coordination Chemistry: Applications
2:30 PM-4:50 PM, Tuesday, March 24, 2009 Salt Palace Convention Center -- Combo Rooms 253 A-B, Oral

Division of Inorganic Chemistry

The 237th ACS National Meeting, Salt Lake City, UT, March 22-26, 2009