AGFD 130 |
| Noni leaves (Morinda citrifolia) have been used in Polynesia as herb tea and for treatment of insect bites, sun burn, and skin diseases for a long time. Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and wound healing. Under the guidance of adenosine A2A receptor binding assay, three bioactive compounds, Pyro-pheophorbide a (IC50=1.5 microgram/mL), 10-Hydroxy-pheophorbide a (IC50=7.0 microgram/mL), and Pheophorbide a phytol ester (IC50=23.1 microgram/mL), have been isolated by chromatography on normal and reverse phase columns and identified by NMR spectra and MS. Purpurin 7 dimethyl ester was also isolated. The assigment of NMR parameters of pheophobides were described. Now, the Noni leaf extract containing these active compounds was used in our products for wound healing, skin protection, and skin defenses. |
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General Papers
1:30 PM-4:10 PM, Wednesday, March 25, 2009 Marriott Downtown -- Salon I, Oral
Division of Agricultural & Food Chemistry |