Laser induced autofluorescence and anti-Stokes fluorescence spectroscopy in breast, colon and lung human biopsies

MEDI 241

Maria Navas-Moreno, and Z. Valy Vardeny. Department of Physics, University of Utah, Salt Lake City, UT 84112
Spectroscopy based cancer diagnosis techniques have been studied intensively mainly because of the clean experimental tools used, their big variety, and the simplification of the biopsies histological study that they provide. These techniques are popular also because of their adopting feasibility to clinical practice and in vivo diagnosis. Among them, laser induced autofluorescence (LIA) has been recently surfaced because it may provide a significant ‘contrast' between cancerous (CA) and grossly (GU) uninvolved samples. We employed LIA using 488 and 532 nm excitation wavelengths on Breast, Colon and Lung paired biopsy samples of CA and GU tissues in both Stokes and anti-Stokes fluorescence (ASF) configurations. The ASF spectroscopy has led to another way of discriminating CA/GU tissues. LIA and ASF respond to two different physical phenomena, and their investigation may deepen our understanding of laser-tissue interaction.

General Poster Session
7:00 PM-9:00 PM, Wednesday, March 25, 2009 Salt Palace Convention Center -- Hall 1, Poster

Division of Medicinal Chemistry

The 237th ACS National Meeting, Salt Lake City, UT, March 22-26, 2009