The study of cationic porphyrin interactions with G-quadruplexes

INOR 164

Liliya A. Yatsunyk, lyatsun1@swarthmore.edu, David Kornfilt, dkornfilt@gmail.com, David Marquardt, dmarqua1@swarthmore.edu, Scott Taylor, scott.godschild86@gmail.com, and Amlan Bhattacharjee, abhatta1@swarthmore.edu. Chemistry and Biochemistry, Swarthmore College, 500 College Ave, Swarthmore, PA 19081
Water soluble cationic porphyrins have been shown to inhibit telomerase activity and act as anti-cancer drugs. The focus of the research presented in this poster is to find variations of these porphyrins that are more effective at performing this inhibition. We conducted the detailed study of the substituents effect on the porphyrin—G-quadruplex DNA binding. Two groups of porphyrins have been investigated. One group includes meso-substituted porphyrins with various benzylic groups attached to the nitrogen atoms of the pyridyl grops. The second group includes novel porphyrins with alkyl substituents on ß-positions and pyridyl groups on meso-positions. Porphyrin synthesis and G-quadruplex binding studies will be presented.
 

Bioinorganic Chemistry: DNA and RNA
7:00 PM-9:00 PM, Sunday, August 17, 2008 Pennsylvania Convention Center -- Hall C, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 18, 2008 Pennsylvania Convention Center -- Hall C, Sci-Mix

Division of Inorganic Chemistry

The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008