New methodologies toward the generation of sultam libraries

WCC 9

Kelly Volp1, Alan Rolfe, arolfe@ku.edu1, Kyle Young1, and Paul R. Hanson, phanson@ku.edu2. (1) Department of Chemistry, University of Kansas, 1251 Wescoe Hall Dr, NIH Center of Excellence in Chemical Methodologies and Library Development (KU-CMLD), Lawrence, KS 66045-7582, (2) Department of Chemistry, University of Kansas, NIH Center of Excellence in Chemical Methodologies and Library Development (KU-CMLD), 1251 Wescoe Hall Dr, Lawrence, KS 66045-7582
The development of new methods to generate fused-bicyclic sulfonamides (sultams) for library production is reported. The first approach employs a key domino Heck-Aza-Michael protocol and the second uses an intramolecular Diels-Alder methodology. A range of diverse libraries has been synthesized using a variety of technical platforms including Chemspeed and Bhodan Block. Scaffold design allows for further diversification at key points using both solution and solid phase reagents to produce sultam libraries for biological screening. These diverse libraries are currently being screened for broad biological activity through the NIH-MLSCN screening network.
 

The Merck Index Women in Chemistry
2:30 PM-4:30 PM, Monday, August 18, 2008 Pennsylvania Convention Center -- Hall C, Poster

Women Chemists Committee

The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008