Efficient synthesis of α-fluorovinyl sulfones via Julia olefination

WCC 13

Maggie He, maggiehe82@hotmail.com, Arun Ghosh, and Barbara Zajc. Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, NY 10031
Efficient synthesis of phenyl α-fluorovinyl sulfones via Julia olefination will be presented. The appropriate fluorinated benzothiazolyl based bis-sulfone reagent was prepared and subjected to condensations with aldehydes and ketones under mild conditions. Stereoselectivity of reactions and comparison of reactivity of this novel reagent to the Horner Wadsworth Emmons reagent will be demonstrated.

 

The Merck Index Women in Chemistry
2:30 PM-4:30 PM, Monday, August 18, 2008 Pennsylvania Convention Center -- Hall C, Poster

Women Chemists Committee

The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008