Developing NMR methodology for functional materials research

PHYS 242

Arno Kentgens, a.kentgens@nmr.ru.nl, Physical Chemistry / Solid State NMR, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands
To address the sensitivity of NMR for mass-limited samples it is worthwhile to miniaturize the detector coil. The latest results in the development of microMAS solenoid-based probeheads will be presented. The dimensions of the developed systems allow the study of spinning microcrystals and (partially) oriented material which will be explored.

The stripline geometry is a superior solution for thin film NMR and microfluidic NMR in terms of sensitivity and resolution. On-chip reaction kinetics and the identification of metabolites in small volumes will be demonstrated. Although great progress in sensitivity and resolution has been achieved fast analyses are still restricted to high concentrations. To improve on sensitivity we implemented dynamic nuclear polarization in this “Process on a Chip” context. Optimization of liquid-state DNP in the microfluidics context will be discussed. This approach holds great promise for studying fast reaction kinetics, catalysis, identification of low concentration compounds in metabolic screening etc.