Synthetic studies towards (+)-Angelmarin: A natural product targeting pancreatic cancer

WCC 15

Christina M Woo, cwoo@wellesley.edu1, Joyce Ngai, kngai@wellesley.edu2, and Dora Carrico-Moniz, dcarrico@wellesley.edu2. (1) Wellesley College, 21 Wellesley College Rd, Unit 5709, Wellesley, MA 02481, (2) Department of Chemistry, Wellesley College, 106 Central Street, Wellesley, MA 02481
Angelmarin is a novel coumarin-based natural product that was isolated from extracts of the medicinal plant Angelica pubescens and found to exhibit toxicity specifically against the pancreatic cancer cell line PANC-1. Progress toward the enantioselective total synthesis of the natural product along with synthetic optimization studies will be presented. The natural product will serve as a scaffold for future investigation of structure activity-relationships in an effort to develop a superior therapeutic agent.
 

The Merck Index Women in Chemistry
2:30 PM-4:30 PM, Monday, August 18, 2008 Pennsylvania Convention Center -- Hall C, Poster

Women Chemists Committee

The 236th ACS National Meeting, Philadelphia, PA, August 17-21, 2008