CHED 1497 |
| The fundamental role of gene expression and the recognition of transcription factors and co-activators as important control elements of cell growth, differentiation, and apoptosis created an ever-increasing interest for these proteins as potential targets for therapeutic intervention in human diseases. The vast array of information available for their molecular structure and mode of action in various biological contexts, combined with the new opportunities offered by the technologies of structure-based design, functional genomics and proteomics are creating an exciting opportunity for the discovery of a new generation of highly selective small molecules for regulation of gene expression. By combining chemical synthesis with the methods of molecular biology and genetics, new strategies of modulating transcription are being developed. This lecture will cover several fundamental aspects of transcription factor-based gene regulation and provide an example of targeting transcription factor-coactivator interactions by exploiting the tissue-specific and gene-specific differences in transcriptional machinery composition. |
|
Chemical Evolution from Origins of Life to Modern Society
1:30 PM-4:55 PM, Tuesday, April 8, 2008 Hilton New Orleans Riverside -- Jasperwood, Oral
Division of Chemical Education |