PHYS 134 |
| An emerging concept, supported by both theory and experiments, is intrinsic ability of proteins to sample functional changes in structure. Because such motions are insensitive to structural details, elastic network models have been broadly used in recent years toward efficiently elucidating such allosteric responses. Another recent application of network models has been the modeling of inter-residue interactions as a Markovian stochastic process, using information theory and spectral graph methods. Recent studies are now elucidating the connection between the physically motivated studies based on elastic network models, and those based on information theory and methods. Application to GroEL-GroES will be presented, where the low frequency mode of motion will be shown to directly affect the interaction between residues that act as ‘messengers' that transmit allosteric signals. Disruption of signals by conformational changes undergone during the global modes of motions emerges as a mechanism of regulating allosteric communication. |
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Multiscale Modeling in Biophysics
8:20 AM-12:20 PM, Monday, April 7, 2008 Morial Convention Center -- Rm. R03, Oral
Division of Physical Chemistry |