Determining the stabilization properties of tubulin binding agents based on molecular modeling

CHED 1291

Kyle Chastain, mbearcat60@hotmail.com, Taylor Alloway, and Maralea Gourley, gourlem@hsu.edu. Department of Chemistry, Henderson State University, Reynolds Rm 315, Arkadelplhia, AR 71999
Many structurally different antimitoic agents interfere with tubulin stabilization. An array of compounds belong to a family of agents that bind to the colchicine domain. A pharmacophore of this structurally diverse domain was generated using molecular modeling. Novel commercially available agents were identified as potential tubulin binding agents. Microtuble assays were performed to determine the stabilizing or destabilizing properties of these agents.
 

Undergraduate Research Poster Session: Medicinal Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008