Fullerenes protect against radiation induced cellular damage

INOR 495

Valerie C. Moore, Valerie.Moore@uth.tmc.edu, Department of Internal Medicine, University of Texas Health Science Center at Houston, 6770 Bertner Avenue THI C964A, Houston, TX 77030, Jodie L. Conyers, Jodie.L.Conyers@uth.tmc.edu, The University of Texas Health Science Center at Houston, 7000 Fannin Street, Houston, TX 77030, and Janice Huff, Human Adaptations and Countermeasures Office, Johnson Space Center, 3600 Bay Area Blvd, Houston, TX 77096.
The unique electronic structure of fullerenes allows for high oxygen radical scavenging properties. This study focuses specifically on a fullerene solubilized by a single PAMAM dendrimer (DF-1) derivative leaving 5 other sites to scavenge radicals. We demonstrate that lymphocytes and crypt cells to readily uptake DF-1. When the cells are irradiated with varying levels of gamma-radiation (0-4 Gy), the DF-1 protects against lipid oxidation, micronuclei formations, and apoptosis by scavenging radical oxygen species. The efficacy DF-1 radiation protection is compared to amifostine (the clinically used gold-standard in radiation protection) and trolox (a vitamin E derivative).
 

Nanoscience - Characterization and Applications
9:00 AM-1:00 PM, Tuesday, April 8, 2008 Morial Convention Center -- Rm. 219, Oral

Division of Inorganic Chemistry

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008