Chemopreventative effect of phytic acid on the MDA-MB-468 African-American breast carcinoma cell line

CHED 797

Takova Wallace, takovablue@yahoo.com1, Ifayet Johnson-Mayo, imayo@gmail.com2, Nichole L Powell, nlpowell@tuskegee.edu1, and Roberta M. Troy2. (1) Department of Chemistry, Tuskegee University, 102 Armstrong Hall, Tuskegee, AL 36088, (2) Department of Biology, Tuskegee University, 102 Armstrong Hall, Tuskegee, AL 36088
Phytic acid (IP6) is found in high concentrations in high fiber diets and exhibits anti-cancer action both in vitro and in vivo. However, to date, the effect of phytic acid on cells of different ethnic origins has not been evaluated. Cell viability studies were conducted on the MDA-MB-468 African-American cancer cell line in a time- and dose- dependent manner and evaluated using MTT assays. Inhibition of cell proliferation was seen with as little as 5 mM IP6. Results obtained were compared to the literature documented inhibitory effects on the MDA-MB-231 Caucasian cell line.
 

Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster

Division of Chemical Education

The 235th ACS National Meeting, New Orleans, LA, April 6-10, 2008