Green asymmetric synthesis, an upper-level undergraduate, research based laboratory course

CHED 405

Colleen M. Wiggins, colleen.wiggins@simmons.edu, Gillian L. Petrozziello, gillian.petrozziello@simmons.edu, Yin Yin Lin, liny@simmons.edu, Christina M. King, christina.king@simmons.edu, Deborah S Bass, deborah.bass@simmons.edu, Jennifer N. Boice, jennifer.boice@simmons.edu, Jessica E. Haffner, haffner@simmons.edu, Henglian Huang, henglian.huang@simmons.edu, Virgina S Liu, virginia.liu@simmons.edu, Brittany M. Oheim, brittany.oheim@simmons.edu, Shun Yi Tsui, shunyitsui@gmail.com, Aisha A. Warsame, aisha.warsame@simmons.edu, Nancy E. Lee, nancy.lee@simmons.edu, and Richard W. Gurney, richard.gurney@simmons.edu. Department of Chemistry, Simmons College, 300 The Fenway, Boston, MA 02115
Three different metric systems have been developed by students in the undergraduate teaching laboratories to assess the “greenness” of a specific chemical and reaction. Equipped with these metrics as tools, students in open-inquiry based teaching laboratories as early as their sophomore year are able to confidently propose, execute and revise their own greener procedures for a given experiment. These metrics supplement but do not replace atom economy, percent atom efficiency and the E-factor. A detailed description of the specific metrics as well as their application to two different open-inquiry based teaching laboratories will be discussed.