CHED 1146 |
| Liposomes possess much promise for use in pharmaceutical delivery because of their ability to encapsulate molecules within their membrane layers and within an inner cavity. This isolation from the outside environment provides protection for sensitive pharmaceuticals and the ability to deliver the drug to a specific target. Catanionic liposomes were prepared using dodecyltrimethylammonium bromide (DTMA+Br-) and potassium perfluorooctane sulfonate (K+PFOS-). Sonication was performed on the resulting mixtures to produce biphasic DTMA+ PFOS- liposomes possessing a lipophilic exterior and fluorophilic interior or a fluorophilic exterior and lipophilic interior. The ionic compound DMDOA+ PFOS- and the associated liposomes were characterized using light scattering, powder x-ray diffraction, infrared spectroscopy, and nuclear magnetic resonance. Once prepared, the liposomes were solubilized in both hydrocarbon and fluorocarbon solvents which were then tested for ability to encapsulate target small molecules. |
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Undergraduate Research Poster Session: Inorganic Chemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |