CHED 231 |
| Previous studies indicate that artificial chemicals introduced into the body accumulate in various structures, particularly in hair. Antidepressants are included in these chemicals. Two classes of antidepressants, TCAs (tricyclic antidepressants) and SSRIs (selective serotonin reuptake inhibitors), were administered by intraperitoneal injections into white-bellied black agouti laboratory mice eight times over the course of three consecutive weeks. Hair was shaved seven days before and twenty-three days after initial administration. The accumulation of Imipramine and Fluoxetine Hydrochloride in the mice hair was quantitatively analyzed using high performance liquid chromatography (HPLC). The study examined the role of pigmentation in the accumulation of antidepressants with the analysis of both the nonpigmented and pigmented hair from the mice. In addition it was investigated how two antidepressants, which affect different neurotransmitters in the brain, accumulated differently within the hair. |
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Undergraduate Research Poster Session: Analytical Chemistry
11:00 AM-1:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |