CHED 798 |
| Predicting RNA secondary and tertiary structures from sequence provides a foundation for understanding structure-function relationships, RNA interactions with other biomolecules, and potential drug targets. We have previously reported thermodynamic parameters for naturally occurring 1x2 nucleotide loops (Badhwar et al., in press) and have shown that the Lu et al. (2006) model to predict the stability of 1x2 loops is accurate. The focus of this project is 1x2 nucleotide loops that rarely occur in nature. Thermodynamic parameters for these loops are reported, and this data is compared to the data for naturally occurring 1x2 nucleotide loops. Results show that there are no significant thermodynamic differences between those loops that occur in nature and those that do not, suggesting that the stability of 1x2 loops alone does not appear to play a role when nature selects the sequence of these loops. |
|
Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, April 7, 2008 Morial Convention Center -- Hall A, Poster
Division of Chemical Education |